企业动态
  • 捷报!新合生物以8项全满分成绩通过2020年NCCL室间质评

    未来,新合生物将充分发挥专业技术优势,为肿瘤临床检测及治疗贡献力量。

  • 抗癌新征程|新合生物新抗原疫苗临床试验正式启动

    新合生物期待通过本项临床试验,进一步观察并确认基于肿瘤新抗原疫苗在治疗中晚期胃癌、食管癌的治疗效果,帮助受试者延长病情稳定性及生存期、提升生活质量。

  • Clustering single-cell RNA-seq data with a model-based deep learning approach

    Single-cell RNA sequencing (scRNA-seq) promises to provide higher resolution of cellular differences than bulk RNA sequencing. Clustering transcriptomes profiled by scRNA-seq has been routinely conducted to reveal cell heterogeneity and diversity. However, clustering analysis of scRNA-seq data remains a statistical and computational challenge, due to the pervasive dropout events obscuring the data matrix with prevailing ‘false’ zero count observations.

  • MATHLA: a robust framework for HLA‑peptide binding prediction integrating bidirectional LSTM and multiple head attention mechanism

    Background: Accurate prediction of binding between class I human leukocyte antigen (HLA) and neoepitope is critical for target identification within personalized T-cell based immunotherapy.
    Results: We present a pan-allele HLA-peptide binding prediction framework-MATHLA which integrates bi-directional long short-term memory network and multiple head attention mechanism.
    Conclusion: Our method demonstrates the necessity of further development of deep learning algorithm in improving and interpreting HLA-peptide binding prediction in parallel to increasing the amount of high-quality HLA ligandome data.

  • Liquid Biopsy Applications in the Clinic

    The global liquid biopsy industry is expected to exceed $US5 billion by 2023. One application of liquid biopsy technology is the diagnosis of disease using biomarkers found in blood, urine, stool, saliva, and other biological samples from patients. These biomarkers could be DNA, RNA, protein, or even a cell. More recently, the use of cell-free DNA from plasma is emerging as an important minimally invasive tool for clinical diagnosis. The development of technology has increased the diversity of its application. Here, we discuss how liquid biopsies have been used in the clinic, and how personalized medicine are likely to use liquid biopsies in the near future.

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